Life span has almost doubled in the last century , and consequently aging-specific diseases are becoming prevalent . However, the pathophysiologic mechanisms underlying most of them are still poorly understood and challenges regarding treatments efficacy and costs persist.
Based on this rationale, in this review we present wide scientific background indicating how a natural bioactive molecule with antioxidant property such as the ozone (O3) can be indicated as a potential new strategy to delay neurodegeneration.
We thus provide scientific evidence to build a consistent rationale to apply for the first time the Oxygen-Ozone (O2-O3) therapy in an early phase of aging decline, when it is still possible to intervene, before to develop a potential neurodegenerative pathology.
The Ozone (O3) molecule and the Oxygen-Ozone (O2-O3) therapy
O3 is a triatomic gaseous molecule which has been used as a powerful oxidant in medicine for more than 150 years (Elvis, Ekta, 2011). In nature, O3 is generated during storms due to the electrical discharges of the rays that react with atmospheric O2 to produce O3. In humans, a revolutionary discovery leaded to demonstrate that neutrophils isolated from human peripheral blood and coated with antibodies can catalyse the generation of O3 by a water oxidation pathway, leading to efficient killing of bacteria. Read the research
